January 30, 2018
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  4. Cholesterol Blocker: How Does it Work?

Cholesterol Blocker works to prevent the absorption of dietary (exogenous) cholesterol, and only cholesterol. Cholesterol Blocker is a chewable, vanilla flavored tablet of plant sterols extracted from soy oil. Plant sterols are nearly completely un-absorbable. Their primary mode of action for blocking cholesterol is to combine with dietary cholesterol to form a new “crystalline matrix” that cannot be absorbed. Additionally, because of a molecular similarity with cholesterol, plant sterols can block cholesterol’s absorption sites along the intestinal wall. An analogy is experienced when you put the wrong key into a locked door. The key may slide in easily enough, but it cannot unlock and open the door.

Even though they cannot be absorbed to any significant degree (only 0 to 2%), plant sterols have been shown to lower serum cholesterol by blocking absorption of dietary cholesterol in all animal species tested from chickens and dogs to humans. Blockage occurs on a milligram-to-milligram basis, meaning that one milligram of plant sterols ingested can block the absorption of one milligram of cholesterol. It works best when the plant sterols enter the digestive tract along with cholesterol containing food. However, plant sterols also block the absorption of cholesterol from bile salts lower in the gut. Bile, which had been made from cholesterol by your own body, breaks down here. This releases cholesterol, which can be re-absorbed and re-circulated unless plant sterols get in the way.

All of this happens in the gastrointestinal tract, that is, outside the body. Inside, the liver is “doing its own thing.” In hypercholesterolemic patients, the liver churns out its own cholesterol at excessive levels, oblivious to what is taking place in the intestines and colon. This is endogenous cholesterol, and is not significantly affected by Cholesterol Blocker. Red rice yeast or statin drugs can inhibit endogenous cholesterol production.

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