Redness, and swelling in sore, aching joints is often characterized by oxidative damage to cells in the affected area. White blood cells (leucocytes) and macrophages, immune cells that travel through tissues looking for damage to clean up, utilize free radicals to dismantle the cellular debris they ingest as part of their cleanup work. Free radicals, inadvertently released during the process, run amok, inflicting some damage to healthy tissue surrounding the original site of injury. Antioxidant agents can help control these biochemical events.
The grape seed extract, CucuWIN® Curcuminoids, ApresFlex® Boswellia serrata extract and bromelain extracted from pineapple stems in Joint Vibrance, are intended to corral and quench the free radicals that participate in joint inflammation. Grape seed extract also helps bind broken collagen fibers in connective tissues (e.g. ligaments, tendons, skin etc.)
ApresFlex® concentrates AKBA, the acronym for 3-O-Acetyl-11-keto-beta-boswellic acid. AKBA is the most active compound of Boswellia serrata extracts. In the biochemical cascade that creates redness & swelling at the cellular level, AKBA is a potent inhibitor of the enzyme, 5-lipoxygenase (5-LOX). 5-LOX is a key enzyme in the synthesis of inflammatory cell messengers (leukotrienes) that are made from the ubiquitous omega-6 fatty acid, arachidonic acid. The dose of ApresFlex® required to quell the manufacture of inflammatory leukotrienes is just 100 mg. That is what you will find in each serving of Joint Vibrance.
CucuWIN® has been shown, in comparative studies, to be 46 times more bioavailable than 95% standardized curcuminoid extract of Turmeric.